Described in the scientific literature more than 30 years ago, the feeling of being lonely is characterized as feeling socially isolated or on the social perimeter. It is noteworthy that feeling lonely does not necessarily mean being physically alone. Loneliness corresponds to a discrepancy between the relationships one wants and the relationships one has, so one can feel socially isolated even when they are among "friends." As the celebrity, George Clooney, said: "Anyone would be lying if they said they did not get lonely at times. The loneliest you will get is in the most public of arenas: you will go to a place and end up in the smallest compartment possible, because it is a distraction to everybody, and you end up not getting to enjoy it like everyone else." Although loneliness makes people feel sad, it has another, less obvious effect on our brain and biology: it triggers a sense in which the world is unsafe, and the brain tilts toward a self-preservation mode.

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