Sometimes, people are amazed to hear that the brains of left-handers are different from those of right-handers. But it is clear that they should differ in some respects: left-handers use their hands (and feet) differently than right-handers do, and they do this often over the course of a lifetime. It is only natural that the parts of the brain that control movements should be different in left-handers and right-handers. Compare this to skilled musicians: they practice fine movements a lot, and this influences their brains. To study exactly how the brains of left- and right-handers differ, we need to look at brain lateralization.
Brain lateralization refers to the fact that the left and right sides of the brain are not the same. The two sides differ in their anatomy, and also in what they do. By the way, lateralization is also found in the rest of the body: the two arms look slightly different, and are capable of doing different things; the heart is lateralized to one side of the body cavity, etc. Left-handers are distinct from right-handers in that they tend to have less lateralization in the brain.

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