The body's first line of defense against viruses is the innate immune system. This has cells and other mechanisms which defend the host from any infection. The cells of the innate system recognize, and respond to, pathogens in a general way.
RNA interference is an important innate defense against viruses. Many viruses have a replication strategy that involves double-stranded RNA (dsRNA). When such a virus infects a cell, it releases its RNA molecule. A protein complex called dicer sticks to it and chops the RNA into pieces. Then a biochemical pathway, called the RISC complex, starts up. This attacks the viral mRNA, and the cell survives the infection.
Rotaviruses avoid this by not uncoating fully inside the cell and by releasing newly produced mRNA through pores in the particle's inner capsid. The genomic dsRNA remains protected inside the core of the virion.

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